I haven't played it, but I've read a little about it. Isn't Destroy All Humans about a pandemic? I'm a sucker for movies like that, so I would probably enjoy playing the game. I'm guessing you would be racing against time to save the world from some deadly virus.
That is what it sounds like to me too. I have never heard of it or the movie. I'm not sure it's a game I would buy - I'm not really into saving everyone because they are going to die! Seems a bit violent to me.